Six years after the events of "Wreck-It Ralph," Ralph and Vanellope, now friends, discover a wi-fi router in their arcade, leading them into a new adventure.

Miles Morales is juggling his life between being a high school student and being Spider-Man. However, when Wilson "Kingpin" Fisk uses a super collider, another Spider-Man from another dimension, Peter Parker, accidentally winds up in Miles' dimension. As Peter trains Miles to become a better Spider-Man, they are soon joined by four other Spider-Men from across the "Spider-Verse". As all these clashing dimensions start to tear Brooklyn apart, Miles must help the others stop Fisk and return everyone to their own dimensions.